Shortly after a new tube of toothpaste goes into use, I start rolling the tube over on itself and putting a binder clip on the end:
The result is an "always full," strangely satisfying, easy-squeezing user experience throughout the life of the tube, and (I hope) less wasted toothpaste. Hat tip to my grandfather who I believe did a version of this, probably with rubber bands.
When a tube is done, there are lots of things you can do with it before throwing it away.
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