I've been running a personal WordPress multisite instance for several years now, and I use it to host a variety of personal and organizational sites, including this one. I really like the ways it allows me to standardize and consolidate my management of WordPress as a tool, while still allowing a lot of flexibility for customizing my sites just as though they were individual self-hosted sites.
For the most part, my use of WordPress in multisite/network mode doesn't have any user-facing implications, especially since I use the WordPress MU Domain Mapping plugin to map custom domain names to every site I launch. As far as anyone visiting my sites knows, it's a standalone WordPress site that looks and works like any other.
The one exception to this has been the URL structure for images and other attachments that I upload to any site hosted on this multisite instance. Whereas the typical WordPress image URL might look like this:
on a multisite instance, there is an directory structure added in to separate each site's uploads into its own subdirectory:
where 25 might be the site's unique site ID within that multisite setup.
There's nothing wrong with this approach and it certainly makes technical sense if you have lots of sites on your multisite instance that are either subdirectories or subdomains of the main multisite domain.